This article reviews the most important and relevant literature published between April 2021 and March 2022 on non-Helicobacter pylori Helicobacter (NHPH) infections in humans and animals. Of note, Helicobacter delphinicola was newly described in this period. The first part of this review focuses on the literature describing gastric NHPH. Many clinical reports have been published, especially those regarding Helicobacter suis with chronic gastritis, gastric mucosa-associated mucosal tissue (MALT) lymphoma, and gastric cancer, which are topics of major clinical interest. The relation of NHPH to neurological diseases in humans, including Parkinson’s disease, is an ongoing problem, and glycan-mediated adhesion of H. suis in acidic conditions is an intriguing topic. Enterohepatic Helicobacter infections are associated with colorectal, hepatic, and breast cancers, as well as alcohol-related liver diseases in animal models. Helicobacter cinaedi bacteraemia has been reported to be related to aortic aneurysm, Legionella pneumonia, and chronic subdural haematoma, and the Bactec Fx system has been demonstrated as useful for these investigations. PCR experiments have given clues on the relationship between Helicobacter bilis and pancreatobiliary cancer, and its pathogenesis by the cytolethal distending toxin, has been demonstrated by functional analysis of protein products.