Work-related stress is on the rise in today’s complex business environment. Stress is an important issue because it can negatively affect favourable work outcomes. The aim of the current study was to investigate the relationships between work-related stress and wellbeing, employee resilience, and recovery quality from work stress among mangers. Furthermore, the potential moderating effect of mindfulness on these relationships was investigated. This study utilised a cross-sectional design to measure the five variables of interest (work stress, mindfulness, employee resilience, recovery quality, and wellbeing) through an online survey. A sample of 181 managers participated. The results suggest that mindfulness levels can buffer the effects that work stress has on employee resilience. The results also showed that work-related stress is negatively related to psychological wellbeing, recovery quality, and employee resilience. Overall, these findings provide foundational research for mindfulness-based work interventions to increase employee resilience among managers.