Neurodegeneration occurs when axons break down and disrupt synapse formation. Axon breakdown can be caused by a variety of stressors, ranging from inflammation to physical damage. In this study, we explore the role of NGF (an axon pro-survival neurotrophin) on axon growth and maintenance. We explore the reintroduction of NGF after deprivation on axon growth and maintenance. To test this, we performed a series of axotomy assays to NGF deprived cells, reintroducing NGF at specific points of the assay.

While nerve growth factor’s (NGF) role in supporting axon development has been previously explored, there are still many unanswered questions when it comes to its role in axonal degeneration. The following study explores NGF signaling in axonal degeneration. Neurons transmit electrical signals throughout the body through long projections called axons that form synapses at the axon terminal.

We found that NGF unexpectedly accelerated degeneration when reintroduced permanently, as well as when reintroduced for a brief period and after axotomy. These findings give insight for potential therapeutic interventions. They prompt further exploration of techniques to alter survival factors for maintenance of axons in disease.