The crystal structure of APOBEC-2 and implications for APOBEC enzymes
The crystal structure of APOBEC-2 and implications for APOBEC enzymes
APOBEC-2 (Apo2) belongs to the Apolioprotein B (APOB) mRNA-editing enzyme catalytic polypeptide (APOBEC) family of cytidine deaminases that modify genes by deaminating cytosines in mRNA coding sequences and cytidines in ssDNA (Franca et al., 2006). APOBEC deaminases have remarkably diverse functions comprising antibody maturation, inactivation of viral genomes including Human Immunodeficiency virus-1 (HIV-1) and Hepatitis B virus (HBV), inhibition of retrotransposition, and RNA editing. The repertoire of APOBECs and their respective activities are continuously expanding to include new functions and sub-classes of the family.
Molecular Biology (degree program), Doctor of Philosophy (degree), College of Letters, Arts and Sciences (school)
Molecular Biology (degree program), Doctor of Philosophy (degree), College of Letters, Arts and Sciences (school)
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