The piston/cylinder pair is the key lubricating interface of axial piston pumps. It suffers from excessive wear due to the huge lateral force, especially under high output pressure. In order to achieve predictive maintenance, it is significant to detect the performance degradation of the piston/cylinder pair. In this paper, a method to predict the wear of the piston/cylinder pair is proposed. The wear regions and corresponding wear depths under different conditions are investigated. The distributive characteristic parameters of the oil film are obtained, which can reflect the load-bearing and lubrication conditions at each region of the friction pair. Based on the oil film characteristic parameters, the most suitable wear model is chosen to calculate the wear depth, and then the entire wear profile of the piston/cylinder pair is obtained. The experimental investigation is carried out, and the results show that the accuracy of the wear regions and corresponding wear depth prediction is high. This method can be used to pump healthy management and choose the suitable working conditions of the axial piston pump.