Group II Introns: Highly Structured yet Dynamic
Copyright policy )Group II Introns: Highly Structured yet Dynamic
RNA splicing, the removal of introns and ligation of exons, is a crucial process during mRNA maturation. Group II introns are large ribozymes that self-catalyze their splicing, as well as their transposition. They are living fossils of spliceosomal introns and eukaryotic retroelements. The yeast mitochondrial Sc.ai5γ is the first identified and best-studied self-splicing group II intron. A combination of biochemical, biophysical, and computational tools enables studying its catalytic properties, structure, and dynamics, while also serving to develop new therapeutic and biotechnological tools. We survey the history of group II intron studies paralleling the trends in RNA methodology with Sc.ai5γ in the spotlight.
- UNIVERSITAET ZUERICH Switzerland
- Univerisity of Zurich Finland
- Department of Chemistry Switzerland
- University of Zurich Switzerland
- Department of Chemistry Austria
10120 Department of Chemistry, RNA labeling, RNA catalysis, RNA splicing, Group II intron, Biophysics, 1600 General Chemistry, Introns, Catalysis, Mitochondria, Chemistry, 540 Chemistry, RNA folding, QD1-999, Biotechnology
10120 Department of Chemistry, RNA labeling, RNA catalysis, RNA splicing, Group II intron, Biophysics, 1600 General Chemistry, Introns, Catalysis, Mitochondria, Chemistry, 540 Chemistry, RNA folding, QD1-999, Biotechnology
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