<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

Thiohistidine Biosynthesis

Name: Thiohistidine Biosynthesis
Creator: Seebeck, Florian
Keywords: 0301 basic medicine, 0303 health sciences, Ergothioneine, Biosynthesis, Methylhistidines, Catalysis, 3. Good health, Ligases, Chemistry, 03 medical and health sciences

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 29 May 2013Embargo end date: 01 Jan 2013 Switzerland Publisher:Swiss Chemical SocietyJournal:CHIMIA, volume 67, page 333 (issn: 0009-4293, eissn: 2673-2424,

Authors: Seebeck, Florian;

doi: 10.2533/chimia.2013.333 , 10.5451/unibas-ep31642

pmid: 23863267

Thiohistidine Biosynthesis

- Summary
- Subjects
- Metrics

Abstract

Ergothioneine and ovothiol A are sulfur-containing histidine derivatives produced by microorganisms including Mycobacterium tuberculosis, Trypanosoma cruzi or Erwinia amylovora and may also play important roles in human physiology. Based on our recent identification of thiohistidine biosynthetic enzymes from Mycobacterium smegmatis and Erwinia tasmaniensis we investigate several aspects of sulfur-based redox biochemistry. For example, we are characterizing the catalytic mechanism of two thiohistidine biosynthetic enzymes which afford O2-dependent sulfur insertion into the C(5)–H and C(2)–H bonds of the imidazolyl side chain of histidine.

Country

Switzerland

Related Organizations

University of Basel
Switzerland

Keywords

Ergothioneine, Biosynthesis, Methylhistidines, Catalysis, Ligases, Chemistry, Oxidative stress, Safrole, Ovothiol, Histidine, Sulfhydryl Compounds, QD1-999, Oxidation-Reduction

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	14
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average