E- and P-Selectin: Differences, Similarities and Implications for the Design of P-Selectin Antagonists
Copyright policy )E- and P-Selectin: Differences, Similarities and Implications for the Design of P-Selectin Antagonists
Selectins form a family of Ca2+-dependent carbohydrate binding proteins that mediate the initial step of leukocyte recruitment in the inflammatory process. Blocking of selectins is therefore considered a promising therapeutic approach to treat acute and chronic inflammatory diseases which are caused by excessive extravasation of leukocytes. This mini-review highlights the major structural differences between E- and P-selectin and summarizes the resulting strategies for the design of selectin antagonists.
- University of Basel Switzerland
Inflammation, Models, Molecular, Membrane Glycoproteins, Antagonist, Anti-Inflammatory Agents, Oligosaccharides, Psgl-1, Chemistry, P-Selectin, Drug Design, Glycomimetics, Cell Adhesion, Leukocytes, Sialyl lewisx, Selectin, E-Selectin, Sialyl Lewis X Antigen, QD1-999, Protein Binding
Inflammation, Models, Molecular, Membrane Glycoproteins, Antagonist, Anti-Inflammatory Agents, Oligosaccharides, Psgl-1, Chemistry, P-Selectin, Drug Design, Glycomimetics, Cell Adhesion, Leukocytes, Sialyl lewisx, Selectin, E-Selectin, Sialyl Lewis X Antigen, QD1-999, Protein Binding
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