Access to Macrocycles with an endo Aryl Ether and an endo Aryl-Aryl Bond, Development and Application
Copyright policy )Access to Macrocycles with an endo Aryl Ether and an endo Aryl-Aryl Bond, Development and Application
Macrocyclization methodologies allowing access to macrocycles having an endo aryl ether and an endo aryl–aryl bond, especially those based on an intramolecular SNAr reaction and the Suzuki-Miyaura reaction, are summarized. Total synthesis of complestatin, a bis-macrocyclic natural product, featuring these two technologies are presented.
- École Polytechnique Fédérale de Lausanne EPFL Switzerland
Complement Pathway, Alternative, Macrocyclization, Peptides, Cyclic, Catalysis, Chemistry, Macrocycle, Vancomycin, Heterocyclic Compounds, Snar reaction, Suzuki-miyaura reaction, Complestatin, QD1-999, Chlorophenols, Ethers
Complement Pathway, Alternative, Macrocyclization, Peptides, Cyclic, Catalysis, Chemistry, Macrocycle, Vancomycin, Heterocyclic Compounds, Snar reaction, Suzuki-miyaura reaction, Complestatin, QD1-999, Chlorophenols, Ethers
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