Artificial Ribonucleases

descriptionPublicationkeyboard_double_arrow_right Article 19 Dec 2001Publisher:Swiss Chemical SocietyJournal:CHIMIA, volume 55, page 1,035 (issn: 0009-4293, eissn: 2673-2424,

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Authors: Robert Häner;

doi: 10.2533/chimia.2001.1035

Artificial Ribonucleases

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Abstract

Chemically modified oligonucleotides serve as tools in fundamental research as diagnostic reagents and pharmaceutical compounds. Various chemical groups can nowadays be linked to oligonucleotides, In particular, synthetic constructs of oligonucleotides and lanthanide complexes can serve as artificial ribonucleases. In this paper, some applications of modified oligonucleotides originating from our research efforts directed at the development of artificial ribonucleases are summarized.

Related Organizations

University of Bern
Switzerland

Keywords

Artificial ribonucleases, Chemistry, Oligonucleotide, Rna, Lanthanide complexes, QD1-999, Rna cleavage

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