This paper presents aerodynamic studies of a blended wing body (BWB) configuration within an European project, MOB. Firstly, the effects of spanwise distribution on the BWB aircraft aerodynamic efficiency were studied through an inverse design approach, combining both a low fidelity panel method and a high fidelity RANS method. Secondly, the BWB aerofoil profiles were optimised for improved performance. Finally, three-dimensional optimisation of the BWB twist and camber distribution were carried out based on continuous and discrete adjoint approaches.