To extrapolate from subscale wind tunnel tests to full-scale flight is a well-recognized problem. It becomes especially critical for present day high performance missiles and aircraft which operate at high angles of attack where separated flow effects often dominate the vehicle aerodynamics. The dynamic effects of flow separation can usually not be simulated at subscale Reynolds numbers. This is illustrated by examples of tests with slender vehicles and high performance aircraft. It is shown how analytic means can be developed establishing theoretical relationships between dynamic and static aerodynamic characteristics and how such means make it possible to extrapolate analytically from subscale tests to full-scale flight. The roll of future high Reynolds number facilities in establishing such 'analytic extrapolation' tools is discussed.