An anisotropic buckling and flutter analysis is developed with allowance for both bending-extensional coupling and bending-twisting coupling within the framework of linear small deflection theory for simply supported general laminated plates. The extended Galerkin method is used to obtain approximate solutions to the coupled governing equations. The effects of various anisotropic stiffness parameters on the static and dynamic stability of laminated plates are evaluated, with particular emphasis on assessing the range of applicability of classical orthotropic plate theory. It is shown that bending-extensional coupling and bending-twisting stiffness terms have a destabilizing effect on buckling and flutter, the effect being more pronounced for a small number of layers. For symmetric plates, the number of layers required for orthotropic plate theory to be applicable is generally less for the buckling problem than for flutter. For square plates, aligning the fibers with the direction of airflow over the plate surface results in the highest flutter dynamic pressure.