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Desensitization to 5-Fluorouracil

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1999 English Publisher:Oceanside Publications Inc.Journal:Allergy and Asthma Proceedings, volume 20, pages 189-191 (issn: 1088-5412,

Authors: Kirk Sperber; Thomas Eppinger;

doi: 10.2500/108854199778553064

pmid: 10389552

Desensitization to 5-Fluorouracil

- Summary
- Subjects
- Metrics

Abstract

Anaphylactic reactions to 5-fluorouracil (5-FU) are uncommon. We report a 40-year-old female with adenocarcinoma of the ovary who had two reactions immediately after being infused with 5-FU. The second reaction occurred despite prophylaxis with steroids and antihistamines. The patient was positive to 5-FU on puncture skin testing even though there was no previous exposure to the drug. We successfully desensitized her to 5-FU using a continuous intravenous protocol with sequential increments in the fusion rates and drug concentrations. This desensitization method may be useful to manage systemic reactions to 5-FU and other drugs.

Related Organizations

Mount Sinai Medical Center
United States
Mount Sinai Hospital
United States

Keywords

Adult, Ovarian Neoplasms, Antimetabolites, Antineoplastic, Adenocarcinoma, Immunoglobulin E, Desensitization, Immunologic, Humans, Female, Fluorouracil, Infusions, Intravenous, Anaphylaxis, Skin Tests

Impact byBIP!

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	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average