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Gaceta Mexicana de Oncología

Article . 2023 . Peer-reviewed

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Gaceta Mexicana de Oncología

Article . 2023

Data sources: DOAJ

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Evaluación inmunopatológica de carcinomas orales de células escamosas: serie de casos

Name: Evaluación inmunopatológica de carcinomas orales de células escamosas: serie de casos
Keywords: Inmunoterapia. Neoplasias orales. Microambiente tumoral., Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

descriptionPublicationkeyboard_double_arrow_right Article 25 Jul 2023 Spanish Publisher:Publicidad Permanyer, SLUJournal:Gaceta Mexicana de Oncolog�a, volume 22 (issn: 2565-005X,

Authors: Vinícius G. de Souza; Damilys J. Santos; Tatiana S. Araújo; Ana G. Silva; Rosy I. Ribeiro; Adriano M. Loyola; Sérgio V. Cardoso; +2 Authors

doi: 10.24875/j.gamo.22000145

Evaluación inmunopatológica de carcinomas orales de células escamosas: serie de casos

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Abstract

La evaluación de la expresión del ligando 1 de muerte programada (PD-L1) es un criterio de elegibilidad para la inmunoterapia anti-PD-L1 en el carcinoma oral de células escamosas (COCE). También deben evaluarse otros componentes del microambiente tisular. Aquí se informaron cuatro casos de carcinoma de células escamosas orales. Se realizaron análisis histopatológicos del grado tumoral y TIL (infiltrado inflamatorio asociado a tumor) e inmunohistoquímica para CD4, CD8 y PD-L1. Los casos se clasificaron según el microambiente tisular en resistencia inmunitaria adaptativa, ignorancia inmunológica, tolerancia o inducción intrínseca. Este análisis destaca la importancia de comprender el microambiente inmunológico que puede presentar el COCE para la identificación de dianas terapéuticas más eficaces contra la enfermedad.

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Keywords

Inmunoterapia. Neoplasias orales. Microambiente tumoral., Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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gold

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