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Journal of the Society of Materials Science Japan
Article . 1972 . Peer-reviewed
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The Dynamic Viscoelastic Study of Clotting Reaction in Fibrinogen-Thrombin Systems

Authors: KAIBARA, Makoto; FUKADA, Eiichi;

The Dynamic Viscoelastic Study of Clotting Reaction in Fibrinogen-Thrombin Systems

Abstract

The reaction order in the formation of fibrin network in the fibrinogen-thrombin solution is determined by the analysis of clotting curves obtained by dynamic viscoelasticity measurements at various concentrations of fibrinogen. It is concluded from the rheological point of view that the clotting curves for elastic modulus and loss modulus can be represented by superposition of two first-order reaction processes with different rate constants respectively. The rate constants obtained from the loss modulus are larger than those from the elastic modulus. The saturated values of the elastic moduli in the two processes increase with the increase of the concentration of fibrinogen. The amplitude dependence of the elastic modulus of the gel supports the presence of the two processes.The elastic modulus in the first process is proportional to the number of crosslinks between the fibrin fibers, and that in the second process is related to the non-linear elongation of fibrin fibers between the crosslinks. The loss modulus in the first process is associated with the polymerization of fibrin, and that in the second process is related to the increasing interaction between the crosslinked fibrin fibers.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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