Carpal tunnel syndrome (CTS) is the most common peripheral compression neuropathy, and results in symptoms of numbness and paraesthesia in the thumb, index finger, middle finger, and half of the ring finger. When CTS symptoms progress and can no longer be managed with non-operative measures, carpal tunnel release (CTR) surgery is indicated. In this case, CTR surgery is performed on a 45-year-old female who presented with many weeks of a pins and needles sensation in her right hand that was most pronounced at night, affecting her ability to sleep, and which was not able to be controlled conservatively. The approach presented here is referred to as the “Mini-Open” CTR technique. A 2 cm longitudinal incision was placed directly over the carpal tunnel, and the transverse carpal ligament was exposed and then released. The wound was closed, and the patient was sent home with instructions to use her hand immediately postoperatively, while avoiding strenuous use until the incision has healed. Splinting and therapy are not required postoperatively.