Certain limitations arise from the persistent consideration of two common relations of islands in the humanities and social sciences: land and sea, and island and continent/mainland. What remains largely absent or silent are ways of being, knowing and doing—ontologies, epistemologies and methods—that illuminate island spaces as inter-related, mutually constituted and co-constructed: as island and island. Therefore, this paper seeks to map out and justify a research agenda proposing a robust and comprehensive exploration of this third and comparatively neglected nexus of relations. In advancing these aims, the paper’s goal is to (re)inscribe the theoretical, metaphorical, real and empirical power and potential of the archipelago: of seas studded with islands; island chains; relations that may embrace equivalence, mutual relation and difference in signification.