The geophysical features of the Orekhovo-Pavlograd mineragenic fault zone and connection with it of endogenous uranium ore objects investigated. The analyse of the data of areal distribution of uranium in the rocks of different ages in the Orekhovo-Pavlograd mineragenic fault zone have been considered in the paper. The foregoing materials have enabled a new position to evaluate the possibility of expanding the mineral resource base of uranium in the Orekhovo-Pavlograd mineragenic fault zone.