
Ketone-prone diabetes (KPD) is considered one of the atypical diabetes syndromes because its presentation can lead to misdiagnosis of the type of diabetes. Patients with KPD present in diabetic ketoacidosis (DKA), but once the DKA resolves, some patients can discontinue insulin and maintain adequate glycemic control with oral agents (1). Here, we present the case of a patient who was diagnosed with type 1 diabetes because of recurrent DKA. KPD was suspected because of his high insulin requirements and signs of insulin resistance. He was transitioned from insulin to a glucagon-like peptide-1 (GLP-1) receptor agonist and attained ideal glycemic control. D.H., a 23-year-old man, was diagnosed with type 1 diabetes in October 2013, when he presented to the hospital in DKA. He required 125 units of insulin glargine daily and 41 units of insulin lispro three times daily with meals to achieve glycemic control. In the subsequent months, he had recurrent episodes of DKA while taking the prescribed amounts of insulin. His physical examination was remarkable for a BMI of 39.1 kg/m2 and the presence of acanthosis nigricans on the neck (Figure 1) and in the axilla bilaterally. Laboratory studies revealed a glucose level of 336 mg/dL, bicarbonate of 8.4 mmol/L, ketones in urine, and an anion gap of …
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