Pressure injuries are a significant clinical challenge that incurs substantial morbidity for patients and cost for healthcare systems. These wounds often develop in the context of prolonged immobility and chronic disease. In this review, the authors outline fundamentals of pressure injury pathophysiology, important considerations in patient assessment, and a basic overview of the medical and surgical management of these complex patients. Additionally, a brief overview of innovative technologies on the horizon in the prevention, detection, and treatment of pressure injuries is presented. This chapter aims to provide baseline knowledge to enable the reader to function as an effective member of the multi-disciplinary team that cares for pressure injury patients. This review contains 2 figures, 5 tables, and 31 references. Keywords: pressure injury, pressure sore, chronic wounds, patient assessment, wound care, wound healing, surgical management, stem cells, prevention, medicine, plastic surgery