Human sex trafficking, often referred to as modern-day slavery, is a major global human rights problem with at least 4.5 million people trafficked for commercial sex annually. Many of these women interface with the medical system regularly, often in women’s health clinics and the emergency departments. Therefore, it is important for healthcare providers to be able to identify red flags for human trafficking, to be able to screen effectively, and to know how to connect patients with resources in the community. It is also important for healthcare providers to be aware of the many long-term health effects related to sexual trauma that victims of human trafficking may develop. OBGYNs are able to have long-lasting impacts on the many survivors of human sex trafficking by screening effectively and providing compassionate, trauma-informed care. This review contains 4 figures, and 3 tables, and 40 references. Keywords: Sexual assault, sexual violence, Intimate partner violence, Human trafficking, Rape, Trauma-informed care, Women, Primary Care, Obstetrics and Gynecology.