Expression of p53 in Inverted Papilloma and Malignancy Associated with Inverted Papilloma
Copyright policy )Expression of p53 in Inverted Papilloma and Malignancy Associated with Inverted Papilloma
To determine the association of p53 protein in malignant cases of inverted papilloma compared with cases of benign inverted papilloma of the sinonasal tract.Case-control study of archived pathologic material.Tertiary care hospital.Archived pathologic material of cases of malignancy associated with inverted papilloma and controls of benign inverted papilloma were obtained from Mount Sinai Hospital. These were subjected to immunohistochemistry for p53. Clinical correlation was obtained by retrospective chart review.Staining of pathologic specimens for p53 and survival or recurrence.Four of the five cases of malignancy associated with inverted papilloma demonstrated overexpression of p53. None of the benign cases of inverted papilloma demonstrated overexpression. Only two of the five patients with malignancy associated with inverted papilloma were alive at 2 years.Overexpression of p53 may serve as a marker for malignant transformation of inverted papilloma.
- Mount Sinai Hospital Canada
Male, Papilloma, Inverted, Gene Expression, Middle Aged, Severity of Illness Index, Survival Rate, Case-Control Studies, Outcome Assessment, Health Care, Humans, Female, Tumor Suppressor Protein p53, Paranasal Sinus Neoplasms, Retrospective Studies
Male, Papilloma, Inverted, Gene Expression, Middle Aged, Severity of Illness Index, Survival Rate, Case-Control Studies, Outcome Assessment, Health Care, Humans, Female, Tumor Suppressor Protein p53, Paranasal Sinus Neoplasms, Retrospective Studies
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).17 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!