TWENT Y-ONE years of observation on the occurrence of salmonellosis in Alaska have been completed, and the findings are reported here. Much of the data presented are the result of detailed bacteriological studies on specimens received routinely in the four diagnostic laboratories of the Alaska Health and Welfare Department's Division of Health. The remainder are from reports made by Grumbles and Maciolek (1), Gordon and Babbott (2), Cullison (3), Fournelle and associates (4), Pauls (5), and Gaub (6), or from direct contact with personnel in hospita,ls and research laboratories in Alaska (personal communications from William H. Gaub, 1952; Alice T. Howarth, 1959; and Jerome P. Schmidt, 1959). At le,ast 60 percent of the isolations were from patients suspected of having enteric infections and from contacts in the course of infrequent epidemiological studies. The remainder were from the work of survey teams examining normal human and animal populations in Eskimo and Indian villages. We have relied upon the written and published reports of these observers, some of whom relied on our laboratories for the bacteriological phases of their projects. Bacteriological procedures used have been modified from time to time, but since 1955 the techniques have closely conformed to those described by Edwards and Ewing (7). The present work is a summation of the results obtained in the study of 246 Salmonellai from various localities throughout Alaska. The most frequent type was Salmonella typhimruium . There were 81 strains isolated since the first of this type was cultured from 2 cases of salmonellosis in a February 1945 foodborne outbreak involving 17 children in a children's home near Auke Bay, Alaska. The remailnder included 25 different serotypes, of which S. typhosa (68 strains) and S. 'montevideo (19 strains) were the next most common types encountered. Five other types fre-quently encountered were S. reading (11 strains), S. muenchen (10 strains), S. oranienburg (7 strains), S. new7port (7 strains), and S. enteritidis (6 strains). The S. typhosa strain isolated February 18, 1938, from a Ketchikan patient was the first Salmonella cultured in Alaska. Since 1944 the specific rank of each antigenically distinguishable type of Salmonella isolated has been verified by the Communicable Disease Center, Public Health Service, Chamblee, Ga., or the Salmonella Typing Center, University of Kentucky, Lexington. In the accompanying table, the serotypes are listed in the order of greatest frequency, and the rarer types, of which only one or two strains were reported, follow in the order of the numbers isolated. The final group of five strains was not classified as to types, but only as to genus and therefore is listed last. Types were distributed among human beings, both children and adults, dogs, fur seal pups, seal lice, and gulls. Three types, S. minnesota (1 strain, dog), S. sandiego (1 strain, gull), and S. enteritidis (6 strains, isolated by Jellison and Milner (8), from fur seal pups and seal lice) came from animal sources and were not isolated from man. Seventeen types, isolated from man, came