Binding of Polonium-210 to Liver Metallothionein

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1991Publisher:JSTORJournal:Radiation Research, volume 126, page 379 (issn: 0033-7587,

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Authors: H V, Aposhian; D C, Bruce;

doi: 10.2307/3577929

pmid: 2034794

Binding of Polonium-210 to Liver Metallothionein

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Abstract

The interactions of 210Po at the molecular level in biological systems have received little study even though this alpha-emitting radionuclide occurs widely in nature. Polonium-210 was given subcutaneously to rats and found to be incorporated into liver metallothionein as judged by a number of criteria including heat stability, acetone precipitation, and chromatography. In vitro studies confirmed this binding. The binding of 210Po to metallothionein has implications that may help explain some of the radiation damage 210Po causes intracellularly.

Related Organizations

University of Arizona
United States

Keywords

Male, Polonium, Rats, Inbred Strains, In Vitro Techniques, Binding, Competitive, Rats, Liver, Animals, Metallothionein, Cadmium, Chromatography, Liquid, Protein Binding

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