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Indirect Radioprotection by Sulfhydryl Compounds: A Model Chemical System

Authors: H, Loman; S, Voogd; J, Blok;

Indirect Radioprotection by Sulfhydryl Compounds: A Model Chemical System

Abstract

It is shown that radicals produced from ethanol, formate, and methanol by OH radical attack are able to destroy the thymine chromophore, with a rate constant of the order of $10^{5}\ M^{-1}\,{\rm sec}^{-1}$ . Addition of small quantities of cysteine protects thymine almost completely. This is explained by H-atom transfer from the sulfhydryl compound to the organic radical thus restoring the parent organic molecule and preventing the reaction of the organic radical with thymine. It is suggested that this type of indirect protection of a DNA constituent may be of importance for the radioprotection of DNA in living cells.

Keywords

Carbon Isotopes, Chromatography, Ethanol, Formates, Methanol, Radiation-Protective Agents, DNA, Models, Biological, Radiation Effects, Models, Chemical, Cysteine, Sulfhydryl Compounds, Thymine

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Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
28
Average
Top 1%
Top 10%
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