Genetic Predispositions and Childhood Cancer
Copyright policy )Genetic Predispositions and Childhood Cancer
This article provides an overview of the problem of genetic susceptibility to childhood cancer with a particular emphasis on problems with ascertaining inherited cancer risk and the role of tumor-suppressor gene mutations in cancer predispositions. The association between neurofibromatosis type 1 and childhood leukemia is used to illustrate some of the issues faced by molecular biologists and genetic epidemiologists in identifying and analyzing at-risk individuals. The problem of incomplete penetrance in cancer susceptibility is presented and potential models are discussed. The article concludes with a number of tentative conclusions from existing data and speculations for future studies.
- University of California, San Francisco United States
Molecular Epidemiology, Neurofibromatosis 1, Models, Genetic, Penetrance, Gene Expression Regulation, Neoplastic, Leukemia, Myeloid, Neoplasms, Humans, Genes, Tumor Suppressor, Disease Susceptibility, Child, Germ-Line Mutation
Molecular Epidemiology, Neurofibromatosis 1, Models, Genetic, Penetrance, Gene Expression Regulation, Neoplastic, Leukemia, Myeloid, Neoplasms, Humans, Genes, Tumor Suppressor, Disease Susceptibility, Child, Germ-Line Mutation
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