This study contributes to the growing body of research on situational determinants of coping. Based on a general population sample of 1556 married men and women, it goes beyond previous efforts in two ways. First, it presents the first large-scale analysis of situational determinants of coping effectiveness in response to a wide variety of stressful life events and chronic difficulties. This analysis documents that previous aggregate analyses overlooked a number of specifications which, when observed, provide insights into the mechanisms of coping effectiveness. Second, it assesses the importance of two empirically generated multivariate coping profiles, passivity and versatility. The study's findings suggest that these profiles are associated significantly with adjustment to stress, that these associations differ across situations, and that they help to interpret the effects of separate coping strategies.