Farm-reared bobwhite quails less than 3 weeks of age experienced high mortality (250 of 400). At necropsy, these birds had multiple 1-to-2-mm pale foci throughout their livers. Histologically, these foci varied from acute hepatocellular necrosis without an inflammatory response to necrosis with infiltrates of mononuclear inflammatory cells and some heterophils. Hepatocytes adjacent to affected areas had large basophilic intranuclear inclusions. A group I avian adenovirus was isolated from affected livers.