
doi: 10.2298/vsp0711773k
pmid: 18050973
<zakljucak> Hepatorenalni sindrom je funkcionalna insuficijencija bubrega u sklopu terminalne insuficijencije jetre. U patogenezi ovog sindroma ucestvuju hemodinamske promene (snizeni srednji arterijski pritisak i perfuzioni pritisak bubrega) i povecano stvaranje sistemskih i bubreznih vazoaktivnih medijatora sa stimulacijom bubreznog simpatickog sistema. Standardna medicinska farmakoloska terapija usmerena je na prethodno navedene patofizioloske poremecaje. U poslednje vreme postupci detoksikacije, npr. jedan od vidova albuminske dijalize, pojavljuju se sve vise u lecenju bolesnika sa HRS, ali se jos ne preporucuju kao standardna procedura. Oba vida lecenja preduzimaju se samo kao premoscenje perioda do transplantacije jetre ili u slucajevima kada se ocekuje oporavak funkcije jetre, jer bubrezna funkcija direktno zavisi od funkcije jetre. Standardna hemodijaliza ne pomaze u poboljsanju funkcije bubrega. Jedino kauzalno resenje ovog problema donosi transplantacija jetre.
Medicine (General), Hepatorenal Syndrome, liver transplantation, portasystemic shunt transjugular intrahepatic, vasoconstrictor agents, drug therapy, R5-920, treatment outcome, dialysis, Humans, hepatorenal syndrome
Medicine (General), Hepatorenal Syndrome, liver transplantation, portasystemic shunt transjugular intrahepatic, vasoconstrictor agents, drug therapy, R5-920, treatment outcome, dialysis, Humans, hepatorenal syndrome
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