Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2002 Italy, Serbia English Publisher:National Library of SerbiaJournal:Journal of the Serbian Chemical Society, volume 67, pages 465-471 (issn: 0352-5139, eissn: 1820-7421,

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Authors: Opsenica D; Pocsfalvi G; Milhous; WK; Solaja; BA;

doi: 10.2298/jsc0207465o

handle: 20.500.14243/213830

Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane

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Abstract

An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl3-oxo-7?,12?-diacetoxy-5?-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 ?g/mL; IC50 (W2) = 0.29 ?g/mL).

Countries

Italy, Serbia

Related Organizations

National Research Council
Sri Lanka
Moldova State University, Institute of Chemistry
Moldova (Republic of)
National Research Council
Italy
CONSIGLIO NAZIONALLE DELE RICERCHE
Italy
University of Belgrade
Serbia

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Keywords

intramolecular, Chemistry, steroid, malaria, peroxide, tetraoxane, QD1-999

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