The function of infilled masonry reinforced concrete (RC) frame buildings during severe events such as blast caused by explosions or earth movement – earthquake and other significant lateral displacement could seriously damage a supporting frame column, causing the frame to collapse completely or partially. The behaviour of a framed structure associated with loss of supporting column as a result of vertical gravitational loading imbalance has received less attention in recent studies. When a supporting column is removed in a framed structure, it is assumed that the member deflection increases significantly, which could be restrained by the infill wall, resulting in contact forces between the infill wall and the frame. These interaction forces have an impact on the distributions of shear forces and bending moments along the frame components, which can contribute to frame stability or failure. The current study aims to address these key issues and gain insight into the performance of infilled-frame activity in the absence of a peripheral supporting column. This study’s methodology is based on a numerical investigation of a typical RC infilled-frame subjected to gravitational loading using the three-dimensional discrete element code (3DEC) model. The scenarios considered include; investigation of the loaded structure with the column in place, without the column in place but supported by an infilled wall and with the effect of lateral load acting on the structure without a peripheral column support. The results indicate that masonry infill walls considerably increase the frame resistance to vertical load action, compared to the resistance of a bare frame up to 18%, therefore, the infill wall could play a major role in maintaining the structural system stability/integrity and reducing the likelihood of a progressive collapse.