Radford published an interesting clinical case report of rural patients taking angiotensin II type 1 (AT1) receptor antagonist – commonly also referred to as angiotensin receptor antagonists, AT1 receptor blockers, angiotensin receptor blockers or ARBs – who experienced a sudden loss of consciousness whilst exercising gently in the heat. The findings in this manuscript support, in a clinical setting, previous experimental observations seen in rats. The article also highlights the potential need for a larger scale controlled study, which includes a rural cohort, to confirm these observations, considering the widespread use of AT1 receptor antagonists.