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Galicia Clínica
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Caracterização de metástases ósseas em neoplasias ocultas e neoplasias previamente diagnosticadas

Authors: Catarin Lucas; Inês Vidal; Joana Costa; Pedro Ribeiro; Adriano Rodrigues;

Caracterização de metástases ósseas em neoplasias ocultas e neoplasias previamente diagnosticadas

Abstract

Introdução: A metastização óssea associa-se, geralmente, a mau prognóstico, com evidência de doença neoplásica avançada. Pretende-se caracterizar uma amostra de doentes internados no hospital com o diagnóstico de metastização óssea, comparando-se os doentes com diagnóstico já conhecido de neoplasia com os doentes sem neoplasia identificada. Material e métodos: Estudo observacional retrospectivo, incluídos doentes com diagnóstico de “neoplasia óssea secundária” ou “metástases ósseas”, no período de 2009 a 2013. Analisados os dados de doentes com metástases ósseas com neoplasia primária conhecida ou oculta. Resultados: Analisados os processos de 94 doentes, média de idades de 69±12.66anos, 68% do sexo masculino. Os sintomas apresentados eram principalmente dorso-lombalgia (34%) e défice de força muscular dos membros (15%). Em 42% dos doentes, existia previamente o diagnóstico de neoplasia. A coluna vertebral constituiu o principal local de metastização. Em 22% dos doentes não se identificou a neoplasia primária. A taxa de mortalidade durante o internamento foi de 14%, e no follow-up após um ano de 31%. Discussão: No estudo efectuado, verifica-se que a mortalidade à data de alta do internamento em doentes com neoplasia conhecida é superior à dos doentes com neoplasia indeterminada, o que não se verifica no follow-up a 1 ano. Pode considerar-se que os doentes com neoplasia previamente conhecida podem apresentar metastização óssea mais tardia, e assim, com pior prognóstico. Conclusão: A disseminação tumoral com expressão através da metastização relaciona-se com um agravamento do prognóstico no follow-up. Introduction: The bone metastasis have usually a bad prognosis, with evidence of advance malignancy. It’s intended to characterize a sample of patients admitted to hospital with the diagnosis of bone metastasis, comparing patients with previous diagnosis of neoplasia with patients without diagnosed neoplasia. Material and methods: A retrospective observational study, included patients with diagnois of “secondary bone cancer” or “bone metastasis”, from 2009 to 2013. Analysed data from patients with bone metastasis with known primary neoplasia or with unknow origin. Results: Analized the process of 94 patientes, mean age 69±12.66 years, 68% male. The symptoms were mostly back pain (34%) and muscular strength deficits (15%). In 42% there was a previous diagnosis of neoplasia. The spine was the primary site of metastasis. In 22% of patients, wasn’t identify the primary tumor. The mortality rate during hospitalization was 14%, and in the follow-up to one year of 31%. Discussion: In the study carried out, it is found that mortality at the end of hospitalization in patients with known neoplasia was higher than of the patient with unknow neoplasia, wich is not the case in the follow-up to one year. It can be regarded that patients with known neoplasia may present later bone metastasis, and therefore, a worst prognosis. Conclusion: The tumor spread with expression through metastasis relates with a worsening of the prognosis in the follow-up.

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Keywords

neoplasia, coluna vertebral, R, Medicine, metástases ósseas, Internal medicine, RC31-1245

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
gold
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