For the past 40 years we have developed a variety of techniques to create scaffolds. Raw materials, mostly polymers, are processed and shaped into different structures depending on various applications in tissue engineering. One of the main obstacles to the correct creation of fully functional tissue substitution is the complexity of the design as well as the manufacturing process itself. The biomaterial scaffold must be designed to perform the function of the native tissue extracellular matrix and still maintain its bioactivity during interaction with patient´s body. In this paper we describe the use of scaffolds in tissue engineering in general.