Pantoprazole drug is utilized for treatment of gastric and duodenum ulcer, utilized as proton pump inhibitor, belongs to group of Benzimidazole. Pantoprazole drug undergoes through acidic medium of the stomach, can be coated with enteric coating polymer after that they will safely distribute the drug in the musculin intestine, for the degradation. Pantoprazole has been prepared by direct compression method utilizing variant excipient on different concentration like crosscarmellose sodium as disintegrating agent, dicalcium phosphate as diluents and mannitol. Direct compression is economic since it requires fewer unit operations, compare to wet granulation method. This direct compression method require less equipment, need low power consumption, less space, short duration, leading to low cost of tablets dosage form. The prepared tablets has been evaluated by different evaluation parameter like hardness, surface morphology, weight variation, friability, percentage yield, and it was found that the results comply with official standards. The in-vitro release has been evaluated utilizing pH 1.2 acidic buffer and pH 6.8 phosphate buffer. The in-vitro release study showed that the prepared and evaluated pantoprazole tablets are capable to sustain release drug in the intestine. Keyword: Pantoprazole sodium, enteric coated, ulcer,in-vitro release.