Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Universidad y Saludarrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Universidad y Salud
Article . 2016 . Peer-reviewed
Data sources: Crossref
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Universidad y Salud
Article
License: CC BY NC
Data sources: UnpayWall
versions View all 1 versions
addClaim

MicroRNAs asociados al Cáncer de Cuello Uterino

Authors: Milena Guerrero Florez; Olivia Alexandra Guerrero Gómez;

MicroRNAs asociados al Cáncer de Cuello Uterino

Abstract

Los microRNAs (miRNAs) tienen especial interés en oncología, se ha demostrado el papel de miRNAs en el control de la expresión de genes reguladores del ciclo celular, alteración génica y su implicación en diferentes tipos de cáncer. En este estudio, se realizó una búsqueda sistemática de literatura científica en bases de datos, que establecieran asociación de miRNAs con Cáncer de Cuello Uterino-CCU. Se analizó la localización genómica y cromosómica de miRNAs, la clasificación funcional, grupos de miRNAs al que pertenecen y su implicación en la progresión del CCU. Como resultado, se incluyeron 139 artículos científicos sobre miRNAs en CCU. Se identificaron 272 miRNAs en total y de ellos 252 miRNAs con expresión diferencial en tejidos cancerosos de cuello uterino; de estos, 97 miRNAs están sobre-expresados y 88 miRNAs infra-expresados. 67 miRNAs tuvieron perfiles de expresión variables. La mayoría de miRNAs asociados al CCU se encontraron en los cromosomas 1, 14, 19 y X, así como en regiones intrónicas e intergénicas. El cromosoma 18 humano contiene el menor número de miRNAs. Se identificaron miRNAs en procesos asociados al control del ciclo celular y respuesta inflamatoria. No obstante, se requieren más estudios para esclarecer los mecanismos de los miRNAs en desarrollo del CCU. Con esta revisión se destaca la importancia de miRNAs como biomarcadores pronóstico y diagnóstico, se brinda una actualización sobre miRNAs asociados al CCU y sus lesiones precursoras y se genera un recurso de recopilación y consulta valioso para orientar investigaciones de medicina molecular en este campo.

Related Organizations
  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    1
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
gold
Related to Research communities
Cancer Research