HTLV-1-associated myelopathy

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2019 English Publisher:Japanese Association of VirologyJournal:Uirusu, volume 69, pages 29-36 (issn: 0042-6857, eissn: 1884-3433,

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Authors: Yoshihisa, Yamano;

doi: 10.2222/jsv.69.29

pmid: 32938892

HTLV-1-associated myelopathy

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Abstract

Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that infects T lymphocytes. HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an intractable neurodegenerative disease caused by HTLV-1 infection just like adult T cell leukemia/lymphoma (ATL) is, developing in a fraction of infected individuals. Here, we review the update information about the new drug development and therapeutic algorithm of HAM/TSP based on the resent research achievement in molecular pathogenesis and biomarkers.

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St. Marianna University School of Medicine
Japan

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