Positive and negative regulation of transcription from HIV provirus
Copyright policy )Positive and negative regulation of transcription from HIV provirus
The RNA genome of retroviruses including human immunodeficiency virus type 1 (HIV-1) will be converted into DNA, called "propvirus". This proviral DNA will be integrated into host cell genome and behave like host genes. Since the step at which the viral RNA genome is converted into DNA will not allow any increase of viral genetic information because of the presence of RNaseH activity inherent to the reverse transcriptase and is responsible for the degradation of viral RNA in forming the DNA:RNA hybrid as the intermediate molecule for this conversion. However, during transcription from proviral DNA into viral RNA, hundreds and even thousands of mRNA encoding viral information will be synthesized by the action of host cellular RNA polymerase II, thus producing a large amount of progeny viral particles after translation and assembly. HIV is unique in that it contains virus-specific transcriptional activator called Tat.
- Nagoya City University Japan
Transcription, Genetic, Sp1 Transcription Factor, Ribonuclease H, NF-kappa B, RNA-Directed DNA Polymerase, Genome, Viral, Chromatin, Histone Deacetylase Inhibitors, Proviruses, Antiretroviral Therapy, Highly Active, DNA, Viral, HIV-1, Butyric Acid, Humans, RNA, Viral, tat Gene Products, Human Immunodeficiency Virus, RNA Polymerase II, RNA, Messenger, Porphyromonas gingivalis
Transcription, Genetic, Sp1 Transcription Factor, Ribonuclease H, NF-kappa B, RNA-Directed DNA Polymerase, Genome, Viral, Chromatin, Histone Deacetylase Inhibitors, Proviruses, Antiretroviral Therapy, Highly Active, DNA, Viral, HIV-1, Butyric Acid, Humans, RNA, Viral, tat Gene Products, Human Immunodeficiency Virus, RNA Polymerase II, RNA, Messenger, Porphyromonas gingivalis
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