Role and regulation of RUNX2 in osteogenesis

descriptionPublicationkeyboard_double_arrow_right Article 23 Oct 2014Publisher:Forum Multimedia Publishing LLCJournal:European Cells and Materials, volume 28, pages 269-286

Authors: Bruderer M; Richards RG; Alini M; Stoddart MJ;

doi: 10.22203/ecm.v028a19

pmid: 25340806

Role and regulation of RUNX2 in osteogenesis

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Abstract

Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its interactions within the osteoblast differentiation pathway are often overlooked. This review aims to summarise the knowledge of its regulation at the transcriptional, translational and post-translational level. In addition, the regulation of RUNX2 by factors commonly used during osteogenic studies will be discussed.

Related Organizations

ETH Zurich
Switzerland
AO Research Institute Davos
Switzerland

Keywords

Orthopedic surgery, Osteoblasts, RUNX2, Gene Expression Regulation, Developmental, Core Binding Factor Alpha 1 Subunit, Stem cells, differentiation, Diseases of the musculoskeletal system, bone, osteogenesis, RC925-935, Osteogenesis, Animals, Humans, transcription factor, RD701-811

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