Xenobiotic Metabolizing and Transporter Genes: Gene–Gene Interactions in Schizophrenia and Related Disorders
Copyright policy )Xenobiotic Metabolizing and Transporter Genes: Gene–Gene Interactions in Schizophrenia and Related Disorders
In this study we explored possible epistasis between CYP2D6 (*3, *4, *5, *6 and *1xN), CYP3A5 (*3), CYP1A2 (*1C and *1F) and ABCB1 (G2677T) in schizophrenia and related disorders.A total of 344 patients diagnosed with schizophrenia and related disorders, and 484 healthy controls participated in the present study. We analyzed gene-gene interactions by multifactor dimensionality reduction.A four-way model including ABCB1 G2677T, CYP3A5*3, CYP1A2*1F and CYP2D6*4 variants had the best overall performances (accuracy: 0.573) and a crossvalidation consistency of 10/10 (permutation testing p < 0.004).Our results suggest a significant involvement of CYPs and transporters in brain metabolism and homeostasis, and provide evidence of gene-gene interactions among xenobiotic metabolizing and transporter genes in the context of schizophrenia.
Adult, Male, ATP Binding Cassette Transporter, Subfamily B, Schizophrenia, Paranoid, Reverse Transcriptase Polymerase Chain Reaction, Brain, Biological Transport, Epistasis, Genetic, Middle Aged, Xenobiotics, Cytochrome P-450 CYP2D6, Psychotic Disorders, Cytochrome P-450 CYP1A2, Case-Control Studies, Data Interpretation, Statistical, Schizophrenia, Cytochrome P-450 CYP3A, Humans, Female, ATP Binding Cassette Transporter, Subfamily B, Member 1
Adult, Male, ATP Binding Cassette Transporter, Subfamily B, Schizophrenia, Paranoid, Reverse Transcriptase Polymerase Chain Reaction, Brain, Biological Transport, Epistasis, Genetic, Middle Aged, Xenobiotics, Cytochrome P-450 CYP2D6, Psychotic Disorders, Cytochrome P-450 CYP1A2, Case-Control Studies, Data Interpretation, Statistical, Schizophrenia, Cytochrome P-450 CYP3A, Humans, Female, ATP Binding Cassette Transporter, Subfamily B, Member 1
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