In vitro Antibiofilm Activity of Bioactive Glass S53P4
Copyright policy )In vitro Antibiofilm Activity of Bioactive Glass S53P4
This work aimed to investigate the ability of different formulations of bioactive glass (BAG)-S53P4 to interfere with bacterial biofilm produced on prosthetic material by methicillin-resistant Staphylococcus aureus and multi-drug-resistant Pseudomonas aeruginosa.Antibiofilm activity of three formulations of bioglass was assessed at different time points through two different analyses: Crystal Violet and confocal laser scanning microscopy assays.Significant differences in the whole biofilm were observed between BAG-S53P4-treated and control samples, while no marked changes in antibiofilm activity were observed among the tested formulations. Data from colorimetric assay were confirmed by confocal laser scanning microscopy analysis, which evidenced the significant reduction in biomass and a decrease of total cell volume when both S. aureus and P. aeruginosa biofilms were treated with BAG-S53P4.BAG-S53P4 can be considered as an excellent adjuvant in the treatment of prosthetic infections related to biofilm.
- Institute of Molecular Genetics Russian Federation
- University of Milan Italy
- Istituti di Ricovero e Cura a Carattere Scientifico Italy
- Department of Biological Sciences Russian Federation
Methicillin-Resistant Staphylococcus aureus, Microscopy, Confocal, bacterial biofilm; bioactive glass; confocal laser scanning microscopy; prosthetic joint infections; prosthetic materials, Microbial Sensitivity Tests, Prostheses and Implants, Staphylococcal Infections, Bacterial Adhesion, Anti-Bacterial Agents, Biofilms, Drug Resistance, Multiple, Bacterial, Pseudomonas aeruginosa, Humans, Pseudomonas Infections, Biomass, Glass
Methicillin-Resistant Staphylococcus aureus, Microscopy, Confocal, bacterial biofilm; bioactive glass; confocal laser scanning microscopy; prosthetic joint infections; prosthetic materials, Microbial Sensitivity Tests, Prostheses and Implants, Staphylococcal Infections, Bacterial Adhesion, Anti-Bacterial Agents, Biofilms, Drug Resistance, Multiple, Bacterial, Pseudomonas aeruginosa, Humans, Pseudomonas Infections, Biomass, Glass
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