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Future Microbiology
Article . 2015 . Peer-reviewed
Data sources: Crossref
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Critical Issues for Klebsiella Pneumoniae KPC-Carbapenemase Producing K. Pneumoniae Infections: A Critical Agenda

Authors: DE ROSA, Francesco Giuseppe; CORCIONE, Silvia; CAVALLO, Rossana; DI PERRI, Giovanni; Bassetti M.;

Critical Issues for Klebsiella Pneumoniae KPC-Carbapenemase Producing K. Pneumoniae Infections: A Critical Agenda

Abstract

The wide dissemination of carbapenemase producing K. pneumoniae (KPC-Kp) has caused a public health crisis of global dimensions, due to the serious infections in hospitalized patients associated with high mortality. In 2014, we aim to review clinical data on KPC-Kp at a time when a pro-active strategy (combating the problem before it is established) is no longer useful, focusing on epidemiology, patient risk profile, infection control, digestive tract colonization and treatment issues such as the role of carbapenems or carbapenem sparing strategies, colistin and resistance, dual carbapenem administration and the role of tigecycline. All these issues are illustrated prospectively to provide a forum for a Consensus strategy when not only intensive care units but also medical and surgical wards are affected by the epidemics.

Country
Italy
Keywords

Cross Infection, Infection Control, colistin; epidemiology; infection control; Klebsiella pneumoniae; KPC; KPC-Kp; mortality; therapy; tigecycline; treatment; Anti-Bacterial Agents; Bacterial Proteins; Carbapenems; Colistin; Cross Infection; Drug Therapy, Computer-Assisted; Humans; Klebsiella Infections; Klebsiella pneumoniae; Minocycline; Risk Factors; beta-Lactamases; Infection Control; Microbiology; Microbiology (medical), Colistin, Minocycline, Tigecycline, beta-Lactamases, Anti-Bacterial Agents, Drug Therapy, Computer-Assisted, Klebsiella Infections, Klebsiella pneumoniae, Bacterial Proteins, Carbapenems, Risk Factors, colistin; epidemiology; infection control; Klebsiella pneumoniae; KPC; KPC-Kp; mortality; therapy; tigecycline; treatment; Anti-Bacterial Agents; Bacterial Proteins; Carbapenems; Colistin; Cross Infection; Drug Therapy, Computer-Assisted; Humans; Klebsiella Infections; Klebsiella pneumoniae; Minocycline; Risk Factors; Tigecycline; beta-Lactamases; Infection Control, Humans

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
41
Top 10%
Top 10%
Top 10%
Green