A Census of RND Superfamily Proteins in the Burkholderia Genus
Copyright policy )A Census of RND Superfamily Proteins in the Burkholderia Genus
The aim of this work was to analyze the eight resistance-nodulation-cell division (RND) families (a group of proteins mainly involved in multidrug resistance of Gram-negative bacteria) in 26 Burkholderia genomes in order to gain knowledge regarding their presence and distribution, to obtain a platform for future experimental tests aimed to identify new molecular targets to be used in antimicrobial therapy against Burkholderia species and to refine the annotation of RND-like sequences in these genomes.A total of 417 coding sequences were retrieved and analyzed using different bioinformatics tools.A complex pattern of RND presence and distribution in the different Burkholderia species was disclosed and a core of proteins represented in all 26 genomes was identified. These 'core' proteins might represent useful targets of new synthetic antimicrobial compounds. Furthermore, the annotation of RND-like sequences in Burkholderia was refined.
- University of Cambridge United Kingdom
- University of Pavia Italy
- National Research Council Italy
- University of Florence Italy
- National Academies of Sciences, Engineering, and Medicine United States
570, antibiotic resistance, Burkholderia, Cystic Fibrosis; RND; Efflux pumps, efflux pumps, Molecular Sequence Data, Computational Biology, Membrane Transport Proteins, new antibiotics, Anti-Bacterial Agents, Protein Structure, Tertiary, Bacterial Proteins, Drug Resistance, Multiple, Bacterial, Multigene Family, Operon, genomics, Amino Acid Sequence, RND, Sequence Alignment, Phylogeny
570, antibiotic resistance, Burkholderia, Cystic Fibrosis; RND; Efflux pumps, efflux pumps, Molecular Sequence Data, Computational Biology, Membrane Transport Proteins, new antibiotics, Anti-Bacterial Agents, Protein Structure, Tertiary, Bacterial Proteins, Drug Resistance, Multiple, Bacterial, Multigene Family, Operon, genomics, Amino Acid Sequence, RND, Sequence Alignment, Phylogeny
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