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Pharmacogenomics

Article . 2008 . Peer-reviewed

Data sources: Crossref

Pharmacogenomics

Article . 2009

Data sources: Europe PubMed Central

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Amodiaquine Pharmacogenetics

Name: Amodiaquine Pharmacogenetics
Creator: Jose Pedro, Gil
Keywords: Polymorphism, Genetic, Endemic Diseases, Plasmodium falciparum, Amodiaquine, Models, Biological, 3. Good health, Antimalarials, 03 medical and health sciences, 0302 clinical medicine, Cytochrome P-450 Enzyme System

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2008Publisher:Informa UK LimitedJournal:Pharmacogenomics, volume 9, pages 1,385-1,390 (issn: 1462-2416, eissn: 1744-8042,

Authors: Jose Pedro, Gil;

doi: 10.2217/14622416.9.10.1385

pmid: 18855526

Amodiaquine Pharmacogenetics

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Abstract

Amodiaquine is a central drug in the new global strategy of combination therapies for the control of malaria. Amodiaquine is mainly metabolized hepatically towards its major active metabolite desethylamodiaquine, by the polymorphic P450 isoform CYP2C8. Amodiaquine is associated with rare but serious side effects, as well as with relatively frequent mild ones. These are expected to be at least partially related to CYP2C8 alleles. Pharmacogenetic knowledge of amodiaquine exposed populations is important for pharmacovigilance issues and in being a first step for future realistic applications from a personal medicine perspective.

Related Organizations

Karolinska Institute
Sweden
University of Algarve
Portugal

Keywords

Polymorphism, Genetic, Endemic Diseases, Plasmodium falciparum, Amodiaquine, Models, Biological, Antimalarials, Cytochrome P-450 Enzyme System, Pharmacogenetics, Animals, Humans, Malaria, Falciparum, Alleles, Forecasting, Half-Life

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	30
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%