This study aims to explore the meaning of life for the interviewees from a more real-life perspective, thus trying to expand the answer to the question of the meaning of life. It goes beyond understanding the meaning of life from the perspective of vague and unclear philosophical concepts. This study analyzes the content of the face-to-face interviews by using the ikigai theory, which demonstrates the influence of cultural formulation, social negotiation, and institutional channeling on the formation of individuals’ meaning of life. Finally, an idea is provide that genetic factors may also influence the formation of meaning in one’s life.