PRIMA-1MET Induces Cellular Senescence and Apoptotic Cell Death in Cholangiocarcinoma Cells

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2019 English Publisher:International Institute of Anticancer ResearchJournal:Cancer Genomics - Proteomics, volume 16, pages 543-552 (issn: 1109-6535, eissn: 1790-6245,

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Authors: Chayanit, Piyawajanusorn; Yingpinyapat, Kittirat; Prakasit, Sa-Ngiamwibool; Attapol, Titapun; Watcharin, Loilome; Nisana, Namwat;

doi: 10.21873/cgp.20156

pmid: 31659107

pmc: PMC6885363

PRIMA-1MET Induces Cellular Senescence and Apoptotic Cell Death in Cholangiocarcinoma Cells

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Abstract

This study examined the in vitro effects of the bile duct cancer drug PRIMA-1MET on cholangiocarcinoma (CCA) cell growth to determine its potential usefulness in CCA therapy.The effect of this drug on the expression of senescent markers (p16INK4A and p21) and the phosphorylation of p53 was investigated, as was the association between senescent markers and the patients' clinicopathological data.PRIMA-1MET inhibited CCA cell growth with the half maximal-inhibitory concentration (IC50) values of 21.9-40.8 μM. PRIMA-1MET induced phospho-p53, p16INK4A and p21 triggering cellular senescence and apoptosis. High expressions of p16INK4A and p21 were associated with a high survival rate of patients with CCA.PRIMA-1MET may potentially be an alternative anticancer agent that might lead to a better prognosis in patients with CCA.

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Keywords

Cholangiocarcinoma, Gene Expression Regulation, Neoplastic, Quinuclidines, Bile Duct Neoplasms, Cell Line, Tumor, Humans, Apoptosis, Cellular Senescence, Neoplasm Proteins

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