In this review, I would like to introduce how we can detect the possible life on Mars. Even though the quantitative estimation of the possibility of biogenesis on Mars is difficult, Dr. McKay and his colleagues work has thrown a tiny light for this possibility. Considering Mars environmental conditions, the possible life is microorganisms. The detection of microorganisms in natural environments is not easy even on Earth due to the premature detection technique. We have developed a method based on the fluorescence microscopic technique. This method proved to be successful for the detection of terrestrial microorganisms. Even some pre-biotic cells can be detected. We are developing a miniature detection apparatus which meet the required standard for installing on the Mars landers. We also propose the ground based experiments using Martian meteorites or pseudo-Martian rocks.