A 50-year-old female patient with minor maxillary defect was afflicted with an ipsilateral oroantral fistula. A unilaterally designed obturator was constructed for the patient. She was satisfied with the obturator because no leakage or seepage into the antrum occurred during mastication. It was also aesthetically acceptable due in particular to the small size of the denture. In this clinical report, treatment with the unilaterally designed obturator is discussed.The use of functional impression techniques during the trial denture stage registered the optimal shape of the soft tissues while they were loaded under a variety of functional conditions. This acted to distribute the functional forces to the saddle area proportionally and prevented any leakage and seepage of food into the defect.The unilaterally designed obturator prosthesis has served to restore masticatory function as well as to obturate the maxillary defect.