Topics of neuromyelitis optica

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2014 English Publisher:Japan Society for Clinical ImmunologyJournal:Japanese Journal of Clinical Immunology, volume 37, pages 468-474 (issn: 0911-4300, eissn: 1349-7413,

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Authors: Katsuichi, Miyamoto;

doi: 10.2177/jsci.37.468

pmid: 25748131

Topics of neuromyelitis optica

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Abstract

Neuromyelitis optica (NMO) has been revealed the difference in the pathology of multiple sclerosis since the anti-aquaporin 4 (AQP4) antibody associated with NMO has been found. The clinical epidemiological study has been reviewed, NMO-related patient number in Japan is estimated to be about 4400 people. The antibody-positive patients against myelin-oligodendrocyte glycoprotein (MOG) are present in anti-AQP4 antibody-negative NMO patients. These patients have a characteristic with high frequency of optic neuritis and good response to therapy. In addition, by research in recent years, a new treatment such as anti-IL-6 therapy or anti-complement therapy has been attempted to NMO.

Related Organizations

Kindai University
Japan

Keywords

Aquaporin 4, Male, Clinical Trials as Topic, Prednisolone, Neuromyelitis Optica, Antibodies, Monoclonal, Humanized, Methylprednisolone, Antibodies, Monoclonal, Murine-Derived, Sex Factors, Japan, Pulse Therapy, Drug, Recurrence, Humans, Drug Therapy, Combination, Female, Molecular Targeted Therapy, Rituximab, Immunosuppressive Agents, Autoantibodies

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